Ewe And Lamb With Teladorsagia

PARAGONE: My First Year Experiences – Dr Dan Price

Dr Dan Price, Moredun Research Institute

I joined Moredun Research Institute a little over 12 months ago and have been working full-time on the European Union funded Horizon 2020 PARAGONE project.  The project aims to move prototype vaccines for animal parasites towards commercial reality.

As I am new to the field of veterinary parasitology, PARAGONE it is great project to be involved with as we have 17 academic and industrial partners from 6 EU countries and places as far away as Uruguay.

In addition PARAGONE has offered plenty of training opportunities, and I recently participated in a next-generation sequencing workshop held here at Moredun.  It was a great opportunity to continue my training and develop new skills in data handling and data analysis. With such a large established network of collaborators and plenty of training opportunities, PARAGONE has allowed me to quickly find my feet and make rapid progress with my work. 

At Moredun, I am working on a vaccine developed by Moredun scientists, which protects sheep against the common roundworm, Teladorsagia circumcincta.   The vaccine is based on vaccinating sheep with a cocktail of 8 proteins.  When the sheep are subsequently exposed to the parasite, they are able to recognize and mount an effective immune response that stops the parasite developing and thus reducing the negative effect of the worm on health and productivity. 

To simplify protein production I am using a new technology to trick yeast into co-producing all eight proteins at the same time.

I am looking forward to the upcoming PARAGONE consortium meeting, which is being hosted by PARAGONE partners at Ghent University, where I will present my work on Teladorsagia circumcincta vaccine development.  I look forward to seeing all of the PARAGONE partners in the upcoming Brussels meeting.