After completing a Medical Doctor degree at Univerity of the Republic of Uruguay (UdelaR) in 1986, I undertook specialist studies at the Dermatology (1987-1989) and Parasitology (1990-1993) Depts. both at the Medical School, UdelaR. From 1981 to 1993, I have held positions as an Instructor, Research Scientist and Assistant Professor at the Dept. of Parasitology, Institute of Hygiene, Montevideo. Since 1994 I have been appointed as Head of the Parasite Biology Unit, Dept. of Cellular and Molecular Biology, School of Sciences, at the Institute of Hygiene.
My research efforts have focused on the helminth parasites Fasciola hepatica (liver fluke) and Echinococcus granulosus (hydatid disease) studying areas such as host immune responses to parasites, parasite proteases and antioxidant enzymes, glycobiology, proteomics and vaccine discovery. This involves characterizing parasite molecules that determine virulence and pathogenesis using genomic and proteomic approaches, with the long term aim of developing vaccines based on these molecules. My research has an international outlook with current collaborations in Argentina, Brazil, Puerto Rico, Peru, Spain, Ireland, Sweden, US, Japan and Australia. I have received grants from national and international funding agencies as well as local and international biotech companies. I have taught extensively particularly organizing the regional course ¨Molecular, biochemical and immunological basis of host-parasite relationship¨.
Particularly relevant to PARAGONE is my extensive experience in organizing and conducting vaccine trials against liver fluke infection in sheep and cattle with the aim of developing a recombinant subunit vaccine, one of the major goals in this project.