The Fundamental and Translational Immunology group, led by Dr Sandra O Neill, studies the innate and adaptive immune response during helminth infection, and its suppressive effects on allergenic and Th1/Th17 driven inflammatory processes. The group’s research particularly focusses on understanding crosstalk between innate immune cells such as dendritic cells, mast cells and macrophage and their role in driving Th2, regulatory and anergenic T-cells.

Another aspect of the research looks at the therapeutic benefits of helminth derived native and recombinant molecules. Understanding how these molecules interact with innate and adaptive immune cells, will identity new mechanisms to control inflammatory processes that could be exploited as novel therapeutics for inflammatory diseases and also as vaccine candidates to prevent helminth infection.