A partnership of academic and commercial organisations working to develop animal vaccines for use on farms in the EU and beyond
PARAGONE PROJECT OVERVIEW
Recently, subunit vaccines designed to control a number of globally important worms of ruminants have shown promise. These parasite vaccines mostly comprise cocktails of several worm proteins. In PARAGONE, the partners will take a number of these prototypes and and test them in further trials, as well combine some to make multivalent vaccines. For parasites for which vaccines have proved difficult to develop, fundamental studies will be performed to inform on the type of host response that needs to be stimulated to obtain protection. This will feed into the selection of appropriate novel adjuvant systems with which to deliver the vaccines. By bringing these streams together, PARAGONE will take the current best multicellular parasite vaccine prototypes forward to practical outcomes for use on farms in the EU and beyond.
Paragone partners outside Moredun Research Institute, April 2015
Cwiklinski, K., Jewhurst, H., McVeigh, P., Barbour, T., Maule, A., Tort, J., Robinson, M., O’Neill, S.M., Donnelly, S. & Dalton, J.P. (2018) Mol Cell Proteomics. 17:792-809. doi:10.1074/mcp.RA117.000445 http://www.mcponline.org/content/17/4/792.long Our study…
Shift of rumen fluke spatial clusters due to flukicide restrictions Between March 2010 and October 2012 only two medications (Albendazole or Oxyclozanide) were licensed for use against liver fluke in…
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Paragone has contributors from academic and industrial institutions across Europe and the rest of the World.